Method for determining the adequacy of dialysis

Surgery – Blood drawn and replaced or treated and returned to body

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210646, A61M 116

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active

053083156

ABSTRACT:
A method for determining the adequacy of dialysis, using determination of urea concentration in the dialysate effluent with an enzymatic urease sensor, and conversion of this information to arterial urea nitrogen utilizing a flow ratio correction; and utilizing the arterial blood urea nitrogen derived from readings of an on-line monitoring sensor as an absolute quantity, and the urea reduction ratio as a relative quantity as a new end-point for dialysis adequacy.

REFERENCES:
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patent: 5230702 (1993-07-01), Lindsay et al.
Gotch et al., A mechanistic analysis of the National Cooperative Dialysis Study (NCDS); Kidney Internat. 28:526-534 (1985).
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Daugirdas, The post:pre dialysis plasma urea nitrogen ratio to estimate K.t/V and NPCR: validation, Int. J. Artif. Organs 12:411-419 (1989).
Garred et al., Urea kinetic Modelling by partial dialysate collection, Int. J. Artif. Organs 12:96-102 (1989).
Brunner et al., Results of Renal Replacement Therapy in Europe, 1980 to 1987, Am. J. Kidney Dis. SV:384-396 (1990).
Lowrie et al., The Urea Reduction Ratio (URR)-A Simple Method for Evaluating Hemodialysis Treatment, Contemp. Dialysis & Nephrol., Feb. 1991:11-19.
Shaldon et al., Survival and Adequacy in Long-Term Hemodialysis, Nephron 59:353-357 (1991).
Vanholder et al., Adequacy of dialysis: A critical analysis, Kindey Internat. 42:540-558 (1992).
Hakim et al., Adequacy of Hemodialysis, Amer. J. Kidney Dis. XX:107-123 (1992).
Keshaviah et al., Clinical Evaluation of a New On-line Monitor of Dialysis Adequacy, J. Amer. Soc. Nephrol. 3:374 (Nov. 1992).

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