Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1992-08-31
1994-12-20
Bidwell, Carol
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 721, 435 79, 435 792, 435 29, 435960, G01N 3353, G01N 33566, G01N 33569
Patent
active
053745329
ABSTRACT:
A method for determining susceptibility to E. coli urinary tract infection comprising assaying a sample of epithelial cells for the presence or absence of at least one of sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and an extended globo structure carrying the same terminal epitopes as sialosyl galactosyl-globoside or disialosyl galactosyl-globoside, or assaying a sample of vaginal secretions for the presence or absence of at least one of sialosyl galactosyl-globoside or disialosyl galactosyl-globoside, and detecting the presence or absence of the at least one of sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and the extended globo structure, a medicament comprising a biologically effective amount of at least one E. coli bacterial receptor analogue and a pharmaceutically acceptable diluent, carrier or excipient as well as a method for preventing E. coli urinary tract infection comprising administering to a host a biologically effective amount of at least one E. coli bacterial receptor or bacterial receptor analogue are disclosed.
REFERENCES:
patent: 5168043 (1992-12-01), Cordon-Cardo et al.
pap-2-Encoded Fimbriae Adhere to the P Blood Group-Related Glycosphingolipid Stage-Specific Embryonic Antigen 4 in the Human Kidney, Joan F. Karr et al., Infection and Immunity, Dec. 1990, pp. 4055-4062.
Stapleton et al. "Binding of Uropathogenic Escherichia coli R45 to Glycolipids Extracted from Vaginal Epithelial Cells is Dependent on Histo-Blood Group Secretor Status". J. Clin. Invest., 90:965-972 (Sep. 1992).
Stapleton et al. "Binding of Uropathogenic Escherichia coli to Glycolipids Extracted from Vaginal Epithelial Cells Collected from Nonsecretors and Secretors of Blood Group Antigens". Clin Res., 39(2):214A (Apr. 1991).
Sheinfeld et al. "Association of the Lewis Blood-Group Phenotype with Recurrent Urinary Tract Infections in Women", N. Eng J. Med., 320(12):773-777 (Mar. 23, 1989).
Leffler et al, "Glycolipid Receptors for Bacterial Adhesion on Human Urinary Tract Epithelium: Relation to Blood Group and Age" in Host Parasite Interactions in Urinary Tract Infections, pp. 93-99 (1989).
Lindstedt et al, "The Receptor Repertoire Defines the Host Range for Attaching Escherichia coli Strains that Recognize Globo-A". Infect. Immun., 59(3):1086-1092 (Mar. 1991).
Hakomori Sen-itiroh
Nudelman Edward
Stamm Walter E.
Stapleton Ann
Bidwell Carol
The Biomembrane Institute
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