Optics: measuring and testing – By dispersed light spectroscopy – With sample excitation
Patent
1998-04-24
2000-04-25
Rosenberger, Richard A.
Optics: measuring and testing
By dispersed light spectroscopy
With sample excitation
G02B 102
Patent
active
060550511
ABSTRACT:
Second harmonic generation (SHG), sum frequency generation (SFG) and difference frequency generation (DFG) can be used for surface analysis or characterization of microparticles having a non-metallic surface feature. The microparticles can be centrosymmetric or such that non-metallic molecules of interest are centrosymmetrically distributed inside and outside the microparticles but not at the surface of the microparticles where the asymmetry aligns the molecules. The signal is quadratic in incident laser intensity or proportional to the product of two incident laser intensities for SFG, it is sharply peaked at the second harmonic wavelength, quadratic in the density of molecules adsorbed onto the microparticle surface, and linear in microparticles density. In medical or pharmacological applications, molecules of interest may be of drugs or toxins, for example.
REFERENCES:
patent: 4448485 (1984-05-01), Bergman et al.
patent: 5348687 (1994-09-01), Beck et al.
patent: 5552086 (1996-09-01), Siiman et al.
Rosenberger Richard A.
The Trustees of Columbia University in the City of New York
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