Method for determining serum cholesterol binding reserve and use

Details Method for determining serum cholesterol binding reserve and use Method for determining serum cholesterol binding reserve and use

1974-04-22

1976-05-04

Wolk, Morris O.

Chemistry: physical processes

Physical processes

Crystallization

G01N 3300

Patent

active

039544095

ABSTRACT:
The ability of serum to bind cholesterol in soluble lipoprotein complexes is believed to retard the deposition of cholesterol in atherosclerotic plaques. This ability is measured by "serum cholesterol binding reserve" (SCBR), defined as the amount of exogenous cholesterol which a serum specimen is capable of solubilizing in addition to its cholesterol content. A method for determining SCBR has been developed. An excess amount of cholesterol is added to a sample of blood serum and incubated. The amount of cholesterol solubilized by the serum is then measured. Test results in case-control studies of premature myocardial infarction have demonstrated the usefulness of SCBR in assessing the risk of coronary heart disease.

REFERENCES:
patent: 3001950 (1961-09-01), Hopper
patent: 3479154 (1969-11-01), Cardinal
patent: 3736263 (1973-05-01), Parekh et al.
patent: 3799739 (1974-03-01), Warburton
J. Clin. Invest., Vol. 52, pp. 1467-1469 (1973).

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