Method for determining sequence alignment significance

Details Method for determining sequence alignment significance Method for determining sequence alignment significance

2006-01-17

2006-01-17

Martinell, James (Department: 1634)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C702S020000

Reexamination Certificate

active

06988039

ABSTRACT:
The present invention relates to methods and systems for quickly determining the statistical significance of a raw alignment score produced by aligning a first sequence to a second sequence. The claimed methods and systems determine multiple estimates of the p-value of an alignment score. Each p-value estimate is then compared to a pre-defined threshold p-value. Depending upon the claimed method employed and further depending upon whether a particular p-value estimate is less than/greater than the threshold p-value, a raw alignment score may be considered statistically significant or insignificant.

REFERENCES:
MPSRCH User/Reference Manual, Version 2.0, Dec. 1994, IntelliGenetics, Inc., Mountain View, CA, USA, pp. 104-109.

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