Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-09-09
2000-02-22
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 235, 536 2431, C12Q 168, C12P 1934, C07H 2104
Patent
active
060278994
ABSTRACT:
A method is provided for determining the propensity or predisposition of a human subject to develop late-onset Alzheimer's disease by the presence in a human subject of a gene (1) for butyrylcholinesterase K variant, and a gene (2) for apolipoprotein E4, the presence of the gene (1) or the presence of both of the above genes (1) and (2) indicating a propensity or predisposition to develop late-onset Alzheimer's disease.
REFERENCES:
patent: 5508167 (1996-04-01), Roses et al.
patent: 5807671 (1998-09-01), Soreq et al.
Mesulam, M.-M. et al, (1992) Cholinesterases in the amyloid angiopathy of Alzheimer's disease, Ann. Neurol. 31, 565-569.
Mesulam, M.-M. et al (1994) Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia, Ann. Neurol. 36, 722-727.
Geula, C. et al, (1995) Cholinesterases and the pathology of Alzheimer disease, Alzheimer Dis. Assoc. Disorders, 9(Suppl. 2), 23-28.
Gomez-Ramos, P. et al (1994) Ultrastructural localization of butyrylcholinesterase on neurofibrillary degeneration sites in the brains of aged and Alzheimer's disease patients, Brain res., 640, 17-24.
Bartels, C.F. et al (1992) DNA mutation associated with the human butyrylcholinesterase K-variant and its linkage to the atypical variant mutation and ot polymorphic sites, Am. J. Hum. Genet. 50, 1086-1103.
Evans, R.T. et al (1984) On the identification and frequency of the J and K cholinesterase phenotypes in a Caucasian population, J. Med. Genet. 21, 99-102.
Whittaker, M. et al (1985) Plasma cholinesterase variants. Family studies of the E.sub.1.sup.k gene, Hum. Hered. 35, 364-368.
Saunders, A.M. et al (1993) Association of apolipoprotein E allele .epsilon.4 with late-onset familial and sporadic Alzheimer's disease, Neurology 43, 1467-1472.
Roses, A.D. (1996) Apoliporotein E alleles as risk factors in Alzheimer's disease, Annu. Rev. Med. 47, 387-400.
Van Rensburg, S.J. et al (1993) Increased frequency of the transferrin C2 subtype in Alzheimer's disease, Neuroreport 4, 1269-1271.
Wright, C.I. et al (1993) Neuroglial cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability, Ann. Neurol., 34, 373-384.
Diedrich, J.F. et al (1991) Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein-E and cathepsin-D in astrocytes, J. Virol, 65, 4759-4768.
Roessmann, U. et al (1966) Changes in butyryl cholinesterase activity in reactive glia, Neurology 16, 123-129.
Weisgraber, K.H. et al (1994) Lipoproteins, neurobiology, and Alzheimer's disease: structure and funciton of apolipoprotein E, Curr. Opin. Struct. Biol., 4, 507-515.
Namba, Y. et al (1991) Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease, Brain Res., 541, 163-166.
Rebeck, G.W. et al (1993) Apolipoprotein-E in sporadic Alzheimer's disease--allelic variation and receptor interactions, Neuron, 11, 575-580.
Nathan, B.P. et al (1994) Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro, Science 264, 850-852.
Hoffman, A. et al (1997) Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam study, Lancet, 349, 151-154.
Lehmann, D.J. et al, "Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease", Human Molecular Genetics, 1997, vol. 11, 1933-1936.
Johnston Carole
Lehmann Donald J.
Smith Anthony David
Bristol--Myers Squibb Company
Myers Carla J.
Rodney Burton
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