Method for determining platelet aggregation

Details Method for determining platelet aggregation Method for determining platelet aggregation

1994-12-29

1996-10-08

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 4, 435183, 435212, 530380, 530381, 530382, 530829, 530830, C12Q 156, C12Q 100, C12N 948, A61K 3514

Patent

active

055630413

ABSTRACT:
The invention relates to a method for determining platelet aggregation in the presence of an inhibitor of fibrin aggregation, which prevents the formation of an interfering fibrin clot, and to a diagnostic aid for determining the platelet aggregation-inhibiting action of thrombin inhibitors.

REFERENCES:
Michelson "Platelet Activation by Thrombin Can Be Directly Measured in Whole Blood Through Use of The Peptide GPRP & Flow Cytometry" Blood Coagul. Fibrinolys. 5121-131 1994.
Kawasaki et al "Amino Acids & Peptides XVI Synthesis of N-Terminal Tetrapeptide Analogs of Fibrin .alpha.-Chain" Chem Pharm Bull 40(12) 3253-3260 1992.
Circ Res. Adelman et al "Synergistic Inhibition of Platelet Aggregation by Fibrinogen Related Peptides" 67(4) 941-947 1990.
S. C. T. Lam et al., Rapid Dissociation of Platelet-Rich Fibrin Clots in Vitro By A Combination of Plasminogen Activators and Antiplatelet Agents, The Journal of Pharmacology & Experimental Therapeutics, 259: 1371-1378, 1991.
A. P. Laudano et al., Synthetic Peptide Derivatives that Bind To Fibrinogen and Prevent the Polymerization of Fibrin Monomers, Proc. Natl. Acad. Sci. U.S.A. 75: 3085-3089, 1978.

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