Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1989-07-05
1992-12-29
Weimar, Elizabeth C.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
800 21, 800DIG1, 4351723, 4353171, 935111, C12N 1500, A61K 4900
Patent
active
051749866
ABSTRACT:
Methods are provided for determining the oncogenic potential of chemical compounds which utilizes a transgenic mouse predisposed to T-cell lymphomas. The transgenic mouse expresses a pim-1 oncogene and as a consequence is predisposed to the spontaneous onset of T-cell lymphomas. The oncogenic potential of a chemical compound is determined by administering a known dose of the chemical compound of interest to a pim-1 transgenic mouse. Thereafter, the transgenic mouse is monitored to detect the onset of a T-cell lymphoma. The time of onset of the T-cell lymphoma and the dosage of the chemical compound are compared to either the onset of spontaneous T-cell lymphomas in the pim-1 transgenic mouse or to the onset of a T-cell lymphoma in a pim-1 transgenic mouse which has been exposed to a known quantity of a carcinogenic agent. This provides an indication of the oncogenic potential of the chemical compound.
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Selten et al., EMBO Journal 4(7): 1793-1798 (1988).
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Berns et al., Proceedings of the Alfred Benzon Symposium 24, vol. 0(0): 211-220 (1987).
Chambers Jasemine C.
GenPharm International Inc.
Weimar Elizabeth C.
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