Method for determining nucleotide sequences

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S287200, C530S350000

Reexamination Certificate

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07943299

ABSTRACT:
The present invention relates to an improved method for determining nucleotide sequences or nucleotide sequences on biochips/micro-assays, for example, using p53 mediated hybridization. The present invention relates particularly to the use of p53 polypeptides in determining changes in nucleotide sequences.

REFERENCES:
patent: 6642000 (2003-11-01), Strizhkov et al.
patent: 1055735 (2000-11-01), None
Bakalkin, G. et al. p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer. Proc. Natl. Acad. Sci. USA 91:413-417 (Jan. 1994).
Westin, L. et al. Antimicrobial resistance and bacterial identification utilizing a microelectronic chip array. Joumal of Clinical Microbiology 39(3):1097-1104 (Mar. 2001).
Anderson, M. and Young, B. “Quantitative filter hybridization,” pp. 73-111 in “Nucleic acid hybridization a practical approach,” Hames and Higgins, eds., 1991.
Piao, X. et al. Effects of mismatches and insertions on discrimination accuracy of nucleic acid probes. Acta Biochimica Polonica 55:713-720 (2008).

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