Method for determining nucleotide identity through primer extens

Details Method for determining nucleotide identity through primer extens Method for determining nucleotide identity through primer extens

1991-03-05

1999-03-30

Arthur, Lisa B.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435 912, C12Q 170, C12Q 168, C12P 1934

Patent

active

058888195

ABSTRACT:
The invention concerns a reagent composition that employs at least two different terminators of a nucleic acid template-dependent primer extension reaction to determine the identity of a nucleotide base at a specific position in a nucleic acid of interest. The invention also concerns the method for determining such identification. The invention may be used to determine the presence or absence of a specific nucleotide sequence in a sample. It may also be employed in determination of genotype and in the identification of different alleles.

REFERENCES:
patent: 4656127 (1987-04-01), Mundy
patent: 4962020 (1990-10-01), Tabor et al.
K. B. Mullis, Scientific American, (Apr. 1990), "The Unusual Origin of the Polymerase Chain Reaction", pp. 56-65.
Prober et al. (1987) Science, vol. 238, pp. 336-341.

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