Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reissue Patent
2007-09-04
2007-09-04
Stucker, Jeffrey (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S003000, C435S005000, C435S041000, C435S069300, C435S325000
Reissue Patent
active
10800361
ABSTRACT:
A method for determining the ion channel activity of a substance comprises the steps of (i) expressing the substance as a heterologous protein in a host cell, and (ii) determining changes in permeability of the plasma membrane of the host cell induced by expression of the heterologous protein. A screening method for determining ion channel modulating activity of a test substance is also disclosed.
REFERENCES:
patent: 4681852 (1987-07-01), Tribe
patent: 5846757 (1998-12-01), Harpold et al.
patent: 34602/89 (1989-11-01), None
Schubert et al. American Society for Microbiology. 1995, p. 63.
Derwent Abstract Accession No. 92-175825/22, Class B04, D16, DD 297186, A (University Berlin Humboldt), Jan. 2, 1992.
Piller et al., “Vpr protein of human immunodeficiency virus type 1 froms cation-selective channels in planar lipid bilayers, PNAC”; vol. 93, pp. 111-115.
Yamato et al., “Site specific alteration of arginine 376 the unique postively charged . . . ”; J. Biol. Chem; vol. 269, No. 8, pp. 5720-5724.
Schubert et al., American Society for Microbiology, 1995, p. 63.
Wolfgan Schreibmayer et al., “Mechanism of modulation of single sodium channels from skeletal muscle by the β1subunit from rat brain”, 1994, European Journal of Physiology, Pflügers Arch, vol. 426, No. 3-4, pp. 360-362.
Cox Graeme Barry
Dulhunty Angela Fay
Ewart Gary Dinneen
Fish & Richardson P.C.
Humphrey Louise
Stucker Jeffrey
The Australian National University
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