Method for determining head and neck squamous cell carcinomas, p

Details Method for determining head and neck squamous cell carcinomas, p Method for determining head and neck squamous cell carcinomas, p

1994-03-01

1996-04-30

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 6, 435 912, 435 71, 435 79, 536 243, 536 231, C12Q 168, C12P 1934, G01N 3353, C07H 2104

Patent

active

055124372

ABSTRACT:
A method for determining head and neck squamous cell carcinomas, bladder tumors and prostate carcinomas is described. The method involves assaying for expression of the gene coding for tumor rejection antigen precursor MAGE-3, or its expression product. Various assays, and kits useful for these assays, are described.

REFERENCES:
Van der Bruggen, et al., "A Gene Encoding an Antigen Recognized By Cytolytic T Lymphocytes On A Human Melanoma", Science 254: 1643-1647 (Dec. 13, 1991).
Brasseur, et al., "Human gene MAGE-1, which codes for a tumor rejection antigen, is expressed by some breast tumors", Int. J. Cancer 52: 839-841 (1992).
Gaugler, et al., "Human Gene MAGE-3 Codes for an Antigen Recognized on a Melanoma by Autologous Cytolytic T Lymphocytes", J. Exp. Med. 179: 921-930 (1994).
Schreiber-"Tumor Immunology" In Fundamental Immunology, William Paul, Raven Press 1989, pp. 923-946.

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