Method for determining haemodynamic indices by use of...

Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C600S407000, C600S410000, C600S415000, C600S419000, C600S425000, C600S431000, C600S432000, C600S436000, C600S476000, C324S307000, C324S308000, C324S309000

Reexamination Certificate

active

07069068

ABSTRACT:
Haemodynamic indices of an organ or a part of tissue are determined from a time series of tomographic data obtained by means of Magnetic Resonance Imaging. Maps of indices are produced, being significant of the dynamics of the capillary tissue flow acquired during rapid bolus injection of a tracer that stays mainly intravascular. The method may be used for evaluating the efficacy of a drug on an organ, or for obtaining information of the likelihood of recovery of an organ or part of tissue upon or during a period of insufficient vascular supply or during the progression of a chronic disease. The method may be used for discriminating between relevant therapy of an organ.

REFERENCES:
patent: 5287273 (1994-02-01), Kupfer et al.
patent: 5377681 (1995-01-01), Drane
patent: 5590654 (1997-01-01), Prince
patent: 5783606 (1998-07-01), Tatton
patent: 5799649 (1998-09-01), Prince
patent: 5853370 (1998-12-01), Chance et al.
patent: 5924987 (1999-07-01), Meaney et al.
patent: 5928148 (1999-07-01), Wang et al.
patent: 6230041 (2001-05-01), Prince
patent: 6397097 (2002-05-01), Requardt
patent: 6760611 (2004-07-01), Watanabe
Bock J C et al.: “Magentic Resonance Perfusion Imaging with Gadolinium-DTPA. A Quantitative Approach for the Kinetic Analysis of First-Pass Residue Curves” Investigative Radiology, vol. 30, No. 12, 1995, pp. 693-699 XP002901064.
Ostergaard L et al.: “High Resolution Measurement of Cerebral Blood Flow using Intravascular Tracer Bolus Passages. Part I: Mathematical Approach and Statistical Analysis” Magnetic Resonance in Medicine, vol. 36, 1996, pp. 715-725, XP002901065.
Ostergaard L et al.: “High Resolution Measurement of Cerebral Blood Flow Using Intravascular Tracer Bolus Passages. Part II: Experimental Comparison and Preliminary Results” Magnetic Resonance in Medicine, vol. 36, 1996, pp. 726-736, XP002901066.
King R B et al.: “Modeling Blood Flow Heterogeneity” Annals of Biomedical Engineering, vol. 24, 1996, pp. 352-372, XP002901067.
Ostergaard L et al.: Cerebral Blood Flow Measurements by Magnetic Resonance Imaging Bolus Tracking: Comparison With [150 ] H2O Journal of Celebral Blood Flow and Metabolism, vol. 18, 1998, pp. 935-940, XP002901068 p. 727.
Schreiber W G et al.: “Cerebral Blood Flow and Cerebrovascular Reserve Capacity: Estimation by Dynamic Magnetic Resonance Imaging” Journal of Cerebral Blood Flow and Metabolism, vol. 18, 1998, pp. 1143-1156, XP002901069.
Ostergaard L et al.: “Absolute Cerebral Blood Flow and Blood Volume Measured by Magnetic Resonance Imaging Bolus Tracking: Comparison With Positron Emission Tomography Values” Journal of Cerebral Blood Flow and Metabolism, vol. 18, 1998, pp. 425-432, XP002901070.
Abounader et al., “Patterns of Capillary Plasma Perfusion in Brains of Conscious Rats During Normocapnia and Hypercapnia,” Circulation Research, vol. 76, No. 1, Jan. 1995, pp. 120-126.
Aronen et al., “Cerebral Blood Volume Maps of Gliomas: Comparison with Tumor Grade and Histologic Findings,” Radiology, vol. 191, No. 1, Apr. 1994, pp. 41-51.
Baron et al., “Reversal of Focal ‘Misery-Perfusion Syndrome’ By Extra-Intracranial Arterial Bypass in Hemodynamic Cerebral Ischemia,” Stroke, vol. 12, No. 4, Jul.-Aug. 1981, pp. 454-459.
Bock, “Pathogenesis of Acute Renal Failure: New Aspects,” Contrib. Nephrol., vol. 124, 1998, pp. 43-63.
Boxerman et al., “MR Contrast due to Intravascular Magnetic Susceptibility Perturbations,” Magn. Reson. Med., vol. 34, 1995, pp. 555-566.
Buell et al., “Combined SPECT Imaging of Regional Cerebral Blood Flow (99mTc-Hexamethyl-Propyleneamine Oxime, HMPAO) and Blood Volume (99mTc-RBC) to Assess Regional Cerebral Perfusion Reserve in Patients with Cerebrovascular Disease,” NuklearMedizin, vol. 27, 1988, pp. 51-56.
Chan et al., “SENSOP: A Derivative-Free Solver for Nonlinear Least Squares with Sensitivity Scaling,” Annals of Biomedical Engineering, vol. 21, 1993, pp. 621-631.
Claudon et al., “Renal Blood Flow in Pigs: Changes Depicted with Contrast-enhanced Harmonic US Imaging during Acute Urinary Obstruction,” Radiology, vol. 212, 1999, pp. 725-731.
Crone, “The Permeability of Capillaries in Various Organs as Determined by Use of the ‘Indicator Diffusion’ Method,” Acta physiol. scand., vol. 58, 1963, pp. 292-305.
Endrich et al., “The Role of the Microcirculation in the Treatment of Malignant Tumors: Facts and Fiction,” Blood Perfusion and microenvironment of human tumors, 1998, pp. 20-39.
Ferrara et al., “Clinical applications of angiogenic growth factors and their inhibitors,” Nature Medicine, vol. 5, No. 12, Dec. 1999, pp. 1359-1364.
Fisel et al., “MR Contrast Due to Microscopically Heterogeneous Magnetic Susceptibility: Numerical Simulations and Applications to Cerebral Physiology,” Magnetic Resonance in Medicine, vol. 17, 1991, pp. 336-347.
Frokiaer et al., “Renal hemodynamic response to ureteral obstruction during converting enzyme inhibition,” Urol Res, vol. 24, 1996, pp. 217-227.
Gibbs et al., “Evaluation of Cerebral Perfusion Reserve in Patients with Carotid-Artery Occlusion,” The Lancet, Feb. 11, 1984, pp. 310-314.
Grubb et al., “The Effects of Changes in PaCO2on Cerebral Blood Volume, Blood Flow, and Vascular Mean Transit Time,” Stroke, vol. 5, Sep.-Oct. 1974, pp. 630-639.
Heiss et al., “Dynamic Penumbra Demonstrated by Sequential Multitracer PET after Middle Cerebral Artery Occlusion in Cats,” Journal of Cerebral Blood Flow and Metabolism, vol. 14, 1994, pp. 892-902.
Hudetz et al., “Effects of Hypoxia and Hypercapnia on Capillary Flow Velocity in the Rat Cerebral Cortex,” Microvascular Research, vol. 54, 1997, pp. 35-42.
Hudetz et al., “Heterogeneous Autoregulation of Cerebrocortical Capillary Flow: Evidence for Functional Thoroughfare Channels?”, Microvascular Research, vol. 51, 1996, pp. 131-136.
Hvistendahl et al., “Renal Hemodynamic Response to Gradated Ureter Obstruction in the Pig,” Nephron, vol. 74, 1996, pp. 168-174.
Iversen et al., “Increased glomerular capillary pressure and size mediate glomerulosclerosis in SHR juxtamedullary cortex,” Am. J. Physiol., vol. 274 (Renal. Physiol., vol. 43), 1998, pp. F365-F373.
Johnson, “Peripheral Circulation,” New York, Wiley, 1973, pp. 1-4.
Kent et al., “Quantitative Cerebral Blood Flow Changes Using Contrast Enhanced MRI: Modulation by Nitric Oxide,” Journal of Cerebral Blood Flow, vol. 17, Suppl. 1, 1997, pp. S14.
King et al., “A vascular transport operator,” Am. J. Physiol., vol. 256, pp. H2196-H2208.
Kroll et al., “Modeling regional myocardial flows from residue functions of an intravascular indicator,” Am. J. Physiol., vol. 271, 1996, pp. H1643-H1655.
Kuschinsky et al., “Capillary Circulation in the Brain,” Cerebrovascular and Brain Metabolism Reviews, vol. 4, 1992, pp. 261-286.
Kwong et al., “Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation,” Proc. Natl. Acad. Sci. USA, vol. 89, Jun. 1992, pp. 5675-5679.
Lammertsma et al., “In VivoMeasurement of Regional Cerebral Haematocrit Using Positron Emission Tomography,” Journal of Cerebral Blood Flow and Metabolism, vol. 4, 1984, pp. 317-322.
Lassen, “Cerebral Transit of an Intravascular Tracer May Allow Measurement of Regional Blood Volume But Not Regional Blood Flow,” Journal of Cerebral Blood Flow and Metabolism, vol. 4, 1984, pp. 633-634.
Leenders et al., “Cerebral Blood Flow, Blood Volume and Oxygen Utilization,” Brain, vol. 113, 1990, pp. 27-47.
Li et al., “Nonlinear Model for Capillary-Tissue Oxygen Transport and Metabolism,” Annals of Biomedical Engineering, vol. 25, 1997, pp. 604-619.
Moseley et al., “Early Detection of Regional Cerebral Isc

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for determining haemodynamic indices by use of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for determining haemodynamic indices by use of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for determining haemodynamic indices by use of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3689199

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.