Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Patent
1998-01-21
2000-10-31
Guzo, David
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
424 932, 424 936, 424 92, 435 6, 435 71, 435 72, 435 29, 4353201, 4352523, 43525231, 43525233, 43525234, 43525235, 536 231, 536 241, A61K 4900, C12N 1563, C12Q 168
Patent
active
061398179
ABSTRACT:
The present invention provides a method for determining pathogen sensitivity to varying levels of reduction of a gene product using an expression vector system having a promoter that is essentially off in vitro and turns on selectively during the infection process in vivo. Genes and gene products identified by this method as essential to growth of infection of a selected pathogen are also provided. In addition, therapeutic compositions designed to target genes identified by this method are provided.
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Palmer Leslie M.
Pratt Julie M.
Rosenberg Martin M.
Gimmi Edward R.
Guzo David
King William T.
Kinzig Charles M.
SmithKline Beecham Corporation
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