Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase
Patent
1990-05-04
1992-03-31
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving oxidoreductase
435 4, 435 25, 424 9, 436133, 436 56, 436 57, 436500, C12Q 126, A61K 4900, G01N 3100, G01N 3348
Patent
active
051007797
ABSTRACT:
A method for determining the function of a unique cytochrome activity of the type which uniquely catalyses the N-demethylation of erythromycin in a patient's body, the method including the steps of ingesting a known quantity of a N-methyl carbon labeled erythromycin solution, the N-methyl carbon demethylated from the erythromycin being metabolized to an exhaled carbon labeled metabolite. A sample of exhaled breath containing a known amount of exhaled carbon metabolite is collected at a known interval of time after ingestion of the erythomycin solution. The quantity of labeled carbon metabolite is detected in the exhaled sample to determine the rate of labeled carbon elimination after the known time interval as an indication of the unique cytochrome function.
REFERENCES:
Bircher et al (1981) Exhalation of Isotopic CO.sub.2, Methods in Enzymology 77:3.9.
The Merick Index 1983, Entries 2748 and 3524.
Bruch et al. (1987) The 14CO.sub.2 Breath Test, Arch. Toxicol. 60:81-5.
Kronbach et al (1988), Cyclosporcie Metabolism in the Human Liver, Clin. Pharm. Ther. 43:630-5.
Brueck et al, Chemical Abstracts, 53776s, vol. 107, 1987.
Coates et al, Chem. Abst, 139172h, vol. 96, 1982.
Wasowicz et al, Chem. Abst. 177490q, vol. 101, 1984.
Wathair et al, Chem. Abst., 1502057z, vol. 110, 1989 (Fourth Record).
Preston David R.
Wax Robert A.
LandOfFree
Method for determining function of a unique cytochrome P-450 act does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for determining function of a unique cytochrome P-450 act, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for determining function of a unique cytochrome P-450 act will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2258393