Method for determining fibrinogen and reagent for determination

Details Method for determining fibrinogen and reagent for determination Method for determining fibrinogen and reagent for determination

1995-08-31

1998-12-22

Alexander, Lyle A.

Chemistry: analytical and immunological testing

Clotting or clotting factor level tests

436 74, 435 13, G01N 3349

Patent

active

058518363

ABSTRACT:
A method for determining fibrinogen concentration whereby thrombin or a protease inhibitor having similar activity thereto is added to an undiluted to test sample to convert fibrinogen in the sample to fibrin, and determining a coagulation time fibrinogen is converted in a reaction mixture containing a salt at a high concentration and a reagent therefor. The determination in the presence of a salt at a high concentration permits simplified determination without diluting the test sample.

REFERENCES:
patent: 4692406 (1987-09-01), Becker et al.
patent: 5223437 (1993-06-01), Hoffman et al.
patent: 5292664 (1994-03-01), Fickenscher
patent: 5508202 (1996-04-01), Enomoto et al.
De Cristofaro et al., Modulation of Thrombin-Fibrinogen Interaction by Specific Ion Effects, Biochemistry, vol. 31, No. 1, 1992, pp. 257-265.
Belitser et al., Ukr. Biokhim. Zh., 5, 567-579 (1975).
Blomback et al., Thrombosis Research, 25, 51-70 (1982).

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