Optics: measuring and testing – Blood analysis
Patent
1990-10-05
1992-06-02
McGraw, Vincent P.
Optics: measuring and testing
Blood analysis
G01N 3349
Patent
active
051181827
ABSTRACT:
Experiments have been conducted which demonstrate that gel optical density is a linear function of the fibrin fiber mass/length ratio (.mu.) and that the slope of the linear function is dependent on the concentration of fibrinogen in the sample. Once the linear function is known, knowledge of a gel optical density at one wavelength is adequate to determine .mu.. Such measurements allow quantitative monitoring of fibrin structure, and are clinically relevant.
REFERENCES:
Clauss, "Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens" Acta Haematol. 17:237-246 (1957).
Carr et al., "Mass-Length Ratio of Fibrin Fibers from Gel Permeation and Light Scattering", Biopolymers, 16:1-15 (1977).
Carr et al., "Size and Density of Fibrin Fibers from Turbidity", Marcomolecules, 13:1473-1477 (1980).
Carr et al., "Dextran-Induced Changes in Fibrin Fiber Size and Density Based on Wavelength Dependence of Gel Turbidity", Marcomolecules, 13:1473-1477 (1980).
Carr et al., "The Effect of Dextran 70 on the Structure of Plasma-Derived Fibrin Gels", J. Clin. Lab. Med., vol. 96, No. 6, pp. 985-993 (1980).
Carr et al., "Influence of Ca.sup.2+ on the structure of reptilase -derived and thrombin-derived fibrin gels", Biochem. J. 239:513-516 (G. Brit.) (1986).
Carr et al., "The Impact of Delayed Fibrinopeptide-A Release on Fibrin Structure", J. Biol. Chem., vol. 262, No. 32, Nov. 15, 1987, pp. 15568-15574.
Carr, "Fluid Phase Coagulation Events Have Minimal Impact on Plasma Fibrin Structure", Amer. J. Med. Sci., vol. 31, No. 5, pp. 433-437 (1988).
Carr et al., "Effect of Glycosaminoglycans on Thrombin- and Antroxin-Induced Fibrin Assembly and Structure", Thrombosis and Haemostatis, vol. 62, No. 4, pp. 1057-1061 (1989).
Carr et al., "Effect of Homo Poly(L-amino acids) on Fibrin Assembly: Role of Charge and Molecular Weight", Biochemistry, vol. 28, No. 3, pp. 1384-1388 (1989).
Carr et al., "Measurement of Plasma Fibrin Fiber Mass-Length Ratios Utilizing Platelet Aggregometers", Clinical Research, vol. 37, No. 2 (Abstract on p. 378A) Apr. 28-May 1, 1989.
Carr et al., "Calculation of Plasma Fibrin Fiber Mass-Length Ratios Utilizing Platelet Aggregometers", Thrombosis Research, 59:183-94 (Jul. 1, 1990).
Center For Innovative Technology
McGraw Vincent P.
Virginia Commonwealth University
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