Method for determining fibrin fiber size from a single gel optic

Details Method for determining fibrin fiber size from a single gel optic Method for determining fibrin fiber size from a single gel optic

1990-04-30

1992-04-21

McGraw, Vincent P.

Optics: measuring and testing

Blood analysis

G01N 3349

Patent

active

051061864

ABSTRACT:
Experiments have been conducted which demonstrate that gel optical density is a linear function of the fibrin fiber mass/length ratio (.mu.). Once the linear function is known, knowledge of a gel optical density at one wavelength is adequate to determine .mu.. Such measurements allow quantitative monitoring of fibrin structure, and are clinically relevant.

REFERENCES:
Clauss, "Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens" Acta Haematol. 17:237-246 (1957).
Carr et al., "Mass-Length Ratio of Fibrin Fibers from Gel Permeation and Light Scattering", Biopolymers, 16:1-15 (1977).
Carr et al., "Size and Density of Fibrin Fibers from Turbidity", Macromolecules, 13:1473-1477 (1980).
Carr et al., "Dextran-Induced Changes in Fibrin Size and Density Based on Wavelength Dependence of Gel Turbidity", Macromolecules, 13:1473-1477 (1980).
Carr et al., "The Effect of Dextran 70 on the Structure of Plasma-Derived Fibrin Gels", J. Clin. Lab. Med., vol. 96, No. 6, pp. 985-993 (1980).
Carr et al., "Influence of Ca.sup.2+ on the Structure of Reptilase-Derived and Thrombin-Derived Fibrin Gels", Biochem. J., 239:513-516 (G. Brit.) (1986).
Carr et al., "The Impact of Delayed Fibrinopeptide-A Release on Fibrin Structure", J. Biol. Chem., vol. 262, No. 32, Nov. 15, 1987, pp. 15568-15574.
Carr, "Fluid Phase Coagulation Events Have Minimal Impact on Plasma Fibrin Structure", Amer. J. Med. Sci., vol. 31, No. 5, pp. 433-437 (1988).
Carr et al., "Effect of Glycosaminoglycans on Thrombin- and Atroxin-Induced Fibrin Assembly and Structure", Thrombosis and Haemostatis, vol. 62, No. 4, pp. 1057-1061 (1989).
Carr et al., "Effect of Homo Poly(L-amino acids) on Fibrin Assembly: Role of Charge and Molecular Weight", Biochemistry, vol. 28, No. 3, pp. 1384-1388 (1989).
Carr et al., "Measurement of Plasma Fibrin Mass-Length Ratios Utilizing Platelet Aggregometers", Clinical Research, vol. 37, No. 2 (Abstract on p. 378A), Apr. 28-May 1, 1989.
Carr et al., "Calculation of Plasma Fibrin Mass-Length Ratios Utilizing Platelet Aggregometers", Thrombosis Research, 59:183-194 (Jul. 1, 1990).

Affiliated with

Also associated with

Rating

Method for determining fibrin fiber size from a single gel optic does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for determining fibrin fiber size from a single gel optic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for determining fibrin fiber size from a single gel optic will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1581477