Method for determining co-receptor selectivity of Human...

Details Method for determining co-receptor selectivity of Human... Method for determining co-receptor selectivity of Human...

2006-03-07

2009-12-29

Nickol, Gary B (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C435S004000

Reexamination Certificate

active

07638319

ABSTRACT:
Newly discovered structural characteristic of the gp120 V3 loop have resulted in a “rule” or algorithm, that is used in a method for determining whether a subject is infected with HIV-1 virus that expresses selectivity for CXCR4 or CCR5 chemokine receptors. A positively charged surface patch defined by V3 loop residues 11 and 24 or 25 at the base of the β-strands in the V3 loop and the homologous β2-β3 chemokine hairpin is responsible for CXCR4 receptor selection. Thus a method for detecting the presence of HIV-1 virus that is selective for X4-co-receptors in a subject infected with HIV-1 or suspected of being infected, from the amino acid sequence of at least a part of the HIV-1 gp120 V3 region peptide that includes residues 11, 24 and 25, or from the nucleotide sequence of a nucleic acid encoding said V3 region peptide, is disclosed.

REFERENCES:
Fa-xin et al., Biological characteristics of HIV-1 isolates circulating in China are linked to its env V3 loop sequence variability, Zhonghua yi xue za zhi ( China ), Dec 2, 2004, 84 (23):1968-72 (Abstract only).
Resch et al., Improved success of phenotype prediction of the human immunodeficiency vrus type I from envelope variable loop 3 sequence using neural networks, Virology, 2001, 288:51-62.
Xiao et al., CCR5 coreceptor usage of non-syncytium-inducing primary HIV-1 is independent of phylogenetically distinct global HIV-1 isolates: delination of consensus motif in the V3 domain that predicts CCR-5 usage, Virology, 1998, 240:83-92.

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