Method for determining analyte concentration using periodic temp

Details Method for determining analyte concentration using periodic temp Method for determining analyte concentration using periodic temp

1999-03-10

2000-12-12

Winakur, Eric F.

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

600309, 600310, 600322, 25033903, 25033907, 2503416, A61B 500

Patent

active

061610283

ABSTRACT:
A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.

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