Method for determining an allergic response

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S353000, C435S372000, C435S383000, C435S392000, C436S506000, C436S507000, C436S513000, C436S015000, C436S020000, C436S021000, C436S022000, C436S023000, C436S035000, C436S063000

Reexamination Certificate

active

07977063

ABSTRACT:
The present invention concerns a method for determining an allergic response by determining the extent of degranulation of human IgE sensitized cells upon activation by allergens in food products.

REFERENCES:
patent: 4559310 (1985-12-01), Cantor et al.
patent: 5714338 (1998-02-01), Wai Fei et al.
patent: 2003/0022250 (2003-01-01), Dreskin et al.
patent: WO 93/25904 (1993-12-01), None
patent: WO 94/12876 (1994-06-01), None
patent: WO 95/15494 (1995-06-01), None
Aketani et al., “Correlation between cytosolic calcium concentration and degranulation in RBL-2H3 cells in the presence of various concentrations of antigen-specific IgEs,”Immunology Letters, Jan. 15, 2001, pp. 185-189, vol. 75, No. 3.
Dibbern et al., “RBL cells expressing human RcRI are a sensitive tool for exploring functional IgE-allergen interactions: studies with sera from peanut-sensitive patients,”Journal of Immunological Methods, Mar. 1, 2003, pp. 37-45, vol. 274, No. 1-2, Elsevier Science Publishers B.V., Amsterdam, NL.

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