Method for determining amount of medication in an implantable de

Details Method for determining amount of medication in an implantable de Method for determining amount of medication in an implantable de

1992-05-04

1993-01-12

Shay, Randy C.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Eye prosthesis

424 9, 424422, 424423, 250302, 6048901, A61F 214

Patent

active

051786354

ABSTRACT:
A system for providing controlled release of an active agent in an eye includes a device with a shape thereof for enabling placement of the device under a conjunctiva of an eye and additionally preventing migration of the device in the eye after placement of the device under the conjunctiva. The device may be formed of a material permeable to the passage of an agent disposed in said device. In addition, a tracer may be incorporated in the device to enable visual indication of the amount of active agent in said device when said device is disposed under the conjunctiva. To selectively treat specific areas of the eye, an impermeable layer may be provided for preventing diffusion of the active agent from a selected area of the device.

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Robinson, "Ophthalmic Drug Delivery Systems" American Pharmaceutical Association, 1980, pp. 104-118.
Sanborn et al. "Sustained-Release Ganciclouir Therapy for Treatment of Retinitis" pp. 188-195, Arch Ophthalmol, vol. 110, Feb. 1992.
Smith et al. "Intravitreal Sustained-Release Ganciclouir" pp. 255-258, Arch Ophthamol, vol. 110, Feb. 1992.
Sedelbeck et al. "Comparing Distribution of Pilocarpine . . . " Amer. Jour. Ophthalmology, pp. 274-283, vol. 80, No. 2, Aug. 1975.
Langer et al. "Medical Applications of Controlled Release" vol. II, CRC Press, 1984, pp. 66-76.
Plister "Customizing Silicone Adhesives for Transdermal Drug Delivery Systems".

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