Chemistry: analytical and immunological testing – Involving iga – igd – ige – or igm
Patent
1984-06-20
1986-12-16
Warden, Robert J.
Chemistry: analytical and immunological testing
Involving iga, igd, ige, or igm
436 34, 436 50, 436 63, 436 69, 436 70, 436517, 73 641, 422 73, 424 91, 435 13, G01N 3349
Patent
active
046297065
ABSTRACT:
A method for determining allergenic sensitivity of a mammal is disclosed. The method involves measuring the time required for hemostasis of a blood sample with an allergen in the presence of a blood clotting inhibitor and comparing the time required for hemostasis in the presence of a blood clotting inhibitor and the absence of the allergen. The sensitivity to the allergen is determined by determining the difference in time required for hemostasis.
REFERENCES:
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patent: 4581920 (1986-04-01), Volkl
J. Immunol., 115:525-532 (1975), R. N. Pinckard, et al., "IgE-Induced Blood Coagulation Alterations in the Rabbit: Consumption of Coagulation Factors XII, XI & IX In Vivo".
Clinical Research, 25:361A (1977), A. P. Kaplan, et al., "Human Anaphylaxis: A Study of Mediator Systems".
J. Immunol., 123:2835-2841 (1979), L. M. McManus, et al., "Platelet Activating Factor (PAF) Induced Release of Platelet Factor 4 (PF4) In Vitro & During IgE Anaphylaxis in the Rabbit".
J. Lab. Clin. Med., 89(6):1306-1313 (1977), J. Blakely, et al. "An In Vitro Measurement of Bleeding Time".
J. Lab. Clin. Med., 81:291 (1973), D. A. Levy, et al., "A Microassay for Studying Allergic Histamine Release from Human Leukocytes Using an Enzymic-Isotopic Assay for Histamine".
Hammond Michael D.
Taylor William J. A.
Benson Robert
Gray Edward P.
Miles Laboratories Inc.
Warden Robert J.
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