Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-11-03
2000-03-28
Arthur, Lisa B.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 231, 536 2433, C12Q 168, C12P 1934, C07H 2104
Patent
active
060430354
ABSTRACT:
A method for determining whether an individual is at increased risk for thrombosis, comprising detecting the presence or absence of a genetic mutation located in the 3' untanslated region of the prothrombin gene (G to A mutation at position 20210) that is correlated with elevated prothrombin levels in individuals with the mutation, wherein the elevated prothrombin levels are associated with increased risk for thrombosis. Also provided are kits and primers that specifically hybridize adjacent to the region of the prothrombin gene that contains the G to A mutation at position 20210.
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S.R. Poort et al., Blood, 88:10:3698-3703, 1996.
S.R. Poort et al., Thromb Haemost, 78:1157-63, 1997.
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Margaglione et al. Ann. Intern. Med.; vol. 129, pp. 89-93, 1998.
Reuner et al. Stroke, vol. 29, pp. 1765-1769, 1998.
Bertina Rogier Maria
Poort Swibertus Rudolfus
Reitsma Pieter Hendrick
Rosendaal Frits Richard
Arthur Lisa B.
Gormley Mary E.
Muir Gregory R.
Rijks University Leiden
Souaya Jehanne
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