Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1993-10-19
1996-03-19
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424467, 424482, A61K 920
Patent
active
055002250
ABSTRACT:
Non-volatile organic components of interest in the urine of humans using diapers are assayed by carrying out the following sequence of steps at least once and up to as many times as the diapers are changed in a given 24-hour period, namely: removing the outer cover and any extraneous material from a used diaper so as to leave only diaper pulp with absorbed urine, estimating the amount of water in the used diaper, extracting a weighed portion of the diaper pulp with a water-miscible organic solvent, in which the diaper pulp is insoluble, to give an extract containing a component of interest, and determining the amount of the component of interest per unit volume of urine absorbed on the diaper pulp by analyzing an aliquot of the extract. The method may be applied e.g. to the prevention of sudden infant death syndrome in infants, by selecting infants for medication with melatonin where diaper urine indicates a deficiency of its metabolite 6-sulfatoxymelatonin in a 24-hour period. The melatonin may be administered in the form of a pharmaceutical formulation, or in an infant food which is included within the invention.
REFERENCES:
patent: 4600723 (1986-07-01), Short et al.
patent: 4654361 (1987-03-01), Samples et al.
patent: 4855325 (1989-08-01), Naftchi
patent: 4945103 (1990-07-01), Cohen
patent: 5023270 (1991-06-01), Goupil
patent: 5151446 (1992-09-01), Horn
Sparks, et al., Journal of Pineal Research, 5:111-118 (1988).
Sparks et al., Sudden Infant Death Syndrome (SIDS) and the Third Eye-II, Abstract No. 127, 5th Coll. Eur. Pineal Study Group, Guilford, U.K., Sep. 2, 1990.
Wurtman et al., Human Pineal Function in Physiologic States and Diseases, Abstract No. 024, 5th Coll. Eur. Pineal Study Group, Guilford, U.K., Sep. 2, 1990.
Wurtman et al., Melatonin in Humans: Possible Involvment in SIDS, and Use in Contraceptives, Advances in Pineal Research 5:319-327 (1991).
Sturner et al., Melatonin Concentrations in the Sudden Infant Death Syndrome, Forensic-Sci-Int. 45:171-80 (1990) (Medline Abstract).
Weissbluth et al., Sudden Infant Death Syndrome: A Genetically Determined Impaired Maturation of the Photoneuroendocrine System. A Unifying Hypothesis, J. Theor. Biol. 167:13-25 (1994) (Medline Abstract).
Laudon et al., Neuroendocrinology, 48,577, 1988.
Laudon Moshe
Zisapel Nava
Benston, Jr. William E.
Neurim Pharmaceuticals (1991) Ltd.
Page Thurman K.
LandOfFree
Method for determination of urine components and for preventing does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for determination of urine components and for preventing , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for determination of urine components and for preventing will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1958063