Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2011-06-21
2011-06-21
Prouty, Rebecca E (Department: 1657)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C436S086000
Reexamination Certificate
active
07964177
ABSTRACT:
Provided is a biomarker that enables easy and rapid detection of oxidative stress on a living organism and enables prevention of tissue damage or cell necrosis by drug administration, and which is a powerful marker for the study of toxicity and pharmacokinetics of various agents. Oxidative stress is determined by measuring blood concentration of ophthalmic acid, which is a substance that varies in blood depending on the variation of reduced glutathione (GSH) concentration in a biological sample with the use of an analyzer such as a capillary electrophoresis-mass spectrometer. Further, an anti-oxidative stress agent is screened by administering an anti-oxidative stress candidate agent to a non-human animal under oxidative stress conditions, measuring blood concentration of ophthalmic acid, and evaluating the degree of decrease in the ophthalmic acid concentration.
REFERENCES:
patent: 6569683 (2003-05-01), Ochi et al.
patent: 2003/0132114 (2003-07-01), Mischak et al.
patent: 11-080198 (1999-03-01), None
patent: 2000-074923 (2000-03-01), None
patent: 2002-517724 (2002-06-01), None
patent: 3341765 (2002-08-01), None
patent: 2003-035698 (2003-02-01), None
patent: 2003-302396 (2003-10-01), None
patent: 2003-532115 (2003-10-01), None
patent: 2003-310621 (2003-11-01), None
patent: 2004-069672 (2004-03-01), None
patent: WO 2005/052575 (2005-06-01), None
Kasai et al. Changes in Ophthalmic Acid and Free Amino Acid in Rats Fed With an Excess Methionine Diet; Agricultural and Biological Chemistry, vol. 53, No. 2 (1989) pp. 553-556.
Schafer and Buettner, “Redox Environment of the Cell As Viewed Through the Redox State of the Glutathione Disulfide/Glutathione Couple,”Free Radic. Biol. Med.30(11):1191-1212 (2001).
European Search Report for European Patent Application No. 07706844.3, dated Jan. 12, 2009.
Soga et al., Differential Metabolomics Reveals Opthalmic Acid as an Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption,J. Biol. Chem., vol. 281: 16768-76, 2006.
International Search Report (PCT/JP2007/050517) mailed Mar. 6, 2007.
Murata “Glutathione-Related Peptides” Protein, Nucleic Acid and Enzyme 33(9):1505-1512 (1988).
English language translation of Murata “Glutathione-Related Peptides”Protein, Nucleic Acid and Enzyme33(9):1505-1512 (1988).
Soga et al., “Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry,”Journal of Proteome Research2:488-494, 2003.
Soga Tomoyoshi
Suematsu Makoto
Clark & Elbing LLP
Keio University
Martin Paul C
Prouty Rebecca E
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