Method for determination of free hormones in biologic fluids

Details Method for determination of free hormones in biologic fluids Method for determination of free hormones in biologic fluids

1978-02-23

1980-09-30

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 424 12, G01N 3316, A61K 4300

Patent

active

042255740

ABSTRACT:
A method for direct determination of the free fraction of an hormone in a biological fluid containing bound and unbound hormone in an equilibrium state. A fluid sample is contacted with a solid matrix capable of reversibly binding the free hormone without sensibly affecting the equilibrium state and the amount of adsorbed hormone is determined and directly correlated with the free hormone in the biological fluid. The method is particularly suitable for direct determination of free thyroxine and triiodothyronine in serum.

REFERENCES:
patent: 4020151 (1977-04-01), Bouz et al.
patent: 4046870 (1977-09-01), Hertl et al.

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