Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving fixed or stabilized – nonliving microorganism,...
Reexamination Certificate
2005-01-28
2008-12-02
Martinell, James (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving fixed or stabilized, nonliving microorganism,...
C435S029000
Reexamination Certificate
active
07459287
ABSTRACT:
The present invention discloses methods for detecting exposure of a living subject to genotoxic agents, testing sensitivity to a genotoxic agent, and determining DNA damage caused by exposure to an agent, comprising detecting the presence of FANCD2-containing foci from a sample collected from said subject. The presence of concentrated foci is indicative of DNA damage, and the degree of foci formation is correlated with degree of exposure. Diagnostic reagents contain a ligand that binds to human FANCD2 associated with a detectable label. Kits for detecting DNA damage in a biological sample contain such diagnostic reagents and signal detection components. The invention further discloses methods for identifying agents which modulate the ability of FANCD2-containing foci to form. Among other things, such agents are potentially useful chemosensitizing agents or may confer protection against damage caused by genotoxic agents.
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Tanaguchi, T. et al. The Franconia anemia protein, FANCE, promotes the nuclear accumulation of FANCC. Blod. Oct. 1, 2002, vol. 100, No. 7, pp. 2457-2462.
Tanaguchi, T. et al., S phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood. Oct. 1, 2002, vol. 100, No. 7, pp. 2414-2420.
Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., and D'Andrea, A. D. (2001). Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell 7, 249-262.
Beaudet Matthew
Dana Farber Cancer Institute, Inc.
Edwards Angell Palmer & & Dodge LLP
Martinell James
Williams Kathleen
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