Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Reexamination Certificate
2005-05-17
2005-05-17
Chin, Christopher (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
C435S002000, C435S007100, C435S007200, C435S007230, C435S007240, C435S007250, C435S007500, C435S007800, C435S007940, C435S040520, C435S174000, C435S181000, C435S961000, C436S513000, C436S518000, C436S523000, C436S526000, C436S532000, C436S534000, C436S538000, C436S540000, C436S824000, C436S828000
Reexamination Certificate
active
06893881
ABSTRACT:
The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating antibodies directed to specific antigen determinants in the target-cell membranes. Incubation of the cell suspension with a mild detergent and/or second set of antibodies or antibody fragments, prelabeled or not with fluorescent agents, metallocolloids, radioisotopes, biotincomplexes or certain enzymes allowing visualization, with dramatically increase the specificity of the method. The method can further be used for isolation of the target-cells by magnetic field application and kit for performing the method according to the invention is described.
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K.M. Stray, et
Fodstad Øystein
Kvalheim Gunnar
Abbott Laboratories Inc.
Chin Christopher
Gabel Gailene R.
Merchant & Gould P.C.
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