Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1988-08-25
1993-02-09
Yarbrough, Amelia Burgess
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 91, 435810, 435975, 436501, 436 94, 536 243, 935 77, 935 78, C12Q 168, C12P 1934, G01N 33566, C01H 1512
Patent
active
051852438
ABSTRACT:
A method is disclosed for detecting the presence of a target nucleotide sequence in a polynucleotide. The method comprises hybridizing a first nucleotide sequence and a second nucleotide sequence to non-contiguous portions of a target nucleotide sequence, covalently attaching the first and second sequences when they are hybridized to the target sequence, and determining the presence of covalently attached first and second sequences. The presence of the covalently attached first and second sequences is related to the presence of the target nucleotide sequence. The invention may be applied to target nucleotide sequences in DNA or RNA. Specific target nucleotide sequences of interest will frequently be characteristic of particular microorganisms, viruses, viroids, or genetic characteristics, including genetic abnormalities.
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Goodman Thomas C.
Stull Paul D.
Ullman Edwin F.
Bosse Mark L.
Burgess Yarbrough Amelia
Leitereg Theodore J.
Syntex (U.S.A.) Inc.
Zitomer Stephanie W.
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