Chemistry: analytical and immunological testing – Biological cellular material tested
Reexamination Certificate
2007-08-14
2007-08-14
Wallenhorst, Maureen M. (Department: 1743)
Chemistry: analytical and immunological testing
Biological cellular material tested
C436S008000, C436S010000, C436S017000, C436S149000, C436S150000, C436S164000, C435S002000, C435S004000, C435S029000, C435S034000
Reexamination Certificate
active
11060957
ABSTRACT:
A method of detecting parasite infection, particularly malaria, includes mixing a blood sample with a lytic reagent system to lyse red blood cells, and to form a sample mixture; performing a differential analysis of white blood cells of the sample mixture on a blood analyzer, and obtaining a cell volume distribution of a white blood cell subpopulation from a cell volume measurement used in the differential analysis; obtaining a cell volume parameter from the cell volume distribution of the white blood cell subpopulation; evaluating the cell volume parameter against a predetermined criterion, and reporting an indication of the parasite infection if the cell volume parameter meets the predetermined criterion. The method also uses a discriminant obtained from cell volume parameters of two different white blood cell subpopulations against a predetermined criterion. The method further use a cell distribution parameter of a cell distribution obtained using a RF impedance measurement.
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Alter Mitchell E.
Beckman Coulter Inc.
Cuspa Technology Law Associates
Wallenhorst Maureen M.
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