Method for detection of exogenous or ACTH stimulated glucocortic

Details Method for detection of exogenous or ACTH stimulated glucocortic Method for detection of exogenous or ACTH stimulated glucocortic

1985-04-25

1987-12-29

Rosen, Sam

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

A61K 4900

Patent

active

047160306

ABSTRACT:
A method for the detection of exogenously administered, or ACTH stimulated, glucocorticoids in domestic animals is provided by first injecting glucagon into a suspected glucocorticoid abused animal and then monitoring the animal's blood glucose levels against an appropriate control over a two hour period. The test measures hepatic carbohydrate metabolism; consequently it is capable of detecting glucocorticoid abuse regardless of the chemical nature of the carrier or base in which the glucocorticoid or ACTH was delivered.

REFERENCES:
Chem. Abst. Gen. Subj. Index-vol. 86-95, (1977-1981) p. 2743GS.
Johnson, R. K.: Insulinoma in the Dog, Vet Clin. North Am., 7(3): 629-635.
Behrans, O. K. and Broner, W: Glucagon, Vitamins and Hormones, vol. XVI-16: 263-301, Academic Press, New York (1958).
Kemppainen, R. J., et al., Adrenocortical Suppression in the Dog Given a Single Intramuscular Dose of Prednisone or Triamcinoline Acetonide, Am. J Vet Res., vol. 42, No. 5, 204-206.
Wellman, M. L., et al., Immunoassay for the Steroid-Induced Isoenzyme of Alkaline Phosphatase in the Dog, Am. J Vet Res., vol. 43, 1200-1204.
Adrenocortical Suppression in the Dog After a Single Dose of Methylprednisolone Acetate, Kemppainen, R. J., et al., Am. J Vet Res., vol. 42, No. 5, 822-824.
Sequential Morphologic and Clinicopatholic Alterations in Dogs with Experimentally Induced Glucocorticoid Hepatopathy, Badylak, S. F., et al., Am. J Vet Res., vol. 42, No. 5, 1310-1317.

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