Method for detection of Cushing's syndrome in domestic animals

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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A61K 4900

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047103701

ABSTRACT:
A method for the detection of Cushing's syndrome in domestic animals is provided by first injecting glucagon into an animal suspected of having Cushing's syndrome and then monitoring the animal's blood glucose levels against an appropriate control over a two hour period. A blood glucose value above about 295 mg/dl is diagnostic for Cushing's syndrome.

REFERENCES:
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Johnson, R. K.: Insulinoma in the Dog, Vet Clin. North Am., 7(3):, 629-635.
Behrans, O. K. and Broner, W.: Glucagon, Vitamins and Hormones, vol. XVI-16, 263-301, Academic Press, New York, (1958).
Kemppainen, R. J., et al., Adrenocortical Suppression in the Dog Given A Single Intramuscular Dose of Prednisone or Triamcinoline Acetonide, Am J Vet Res, vol. 42, No. 5, 204-206.
Wellman, M. L., et al., Immunoassay for the Steroid-Induced Isoenzyme of Alkaline Phosphatase in the Dog, Am J Vet Res, vol. 43, 1200-1204.
Adrenocortical Suppression in the Dog After A Single Dose of Methylprednisolone Acetate, Kemppainen, R. J., et al., AM J Vet Res, vol. 42, No. 5, 822-824.
Sequential Morphologic and Clinicopatholic Alterations in Dogs with Experimentally Induced Glucocorticoid Hepatopathy, Babylak, S. F., et al., AM J Vet Res, vol. 42, No. 5, 1310-1317.

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