Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-06-12
2007-06-12
Fredman, Jeffrey (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C424S009200, C436S501000, C530S300000, C530S350000, C536S023100, C536S063000, C435S320100
Reexamination Certificate
active
08448444
ABSTRACT:
We have now discovered that eukaryotes, including mammals, have a DNA mismatch repair pathway analogous to the pathway that exists in bacteria. Defects or alterations in this mismatch repair pathway in a mammal, such as a human, will result in the accumulation of unstable repeated DNA sequences. Such a phenotype has a high correlation to disease state in a number of cancers, such as hereditary colon cancers. Accordingly, discovering a defect or alteration in the pathway can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer.
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Fishel Richard
Kolodner Richard D.
Reenan Robert A. G.
Dana Farber Cancer Institute, Inc.
Elrifi Ivor R.
Fredman Jeffrey
Kozakiewicz Cynthia A.
Mintz Levin
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