Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-06
2000-10-17
Davenport, Avis M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 536 2372, 536 245, 530403, 4241861, 4241841, 4242041, 435 691, 435 693, 435 712, 435 711, 435 911, 4351721, C07H 1900, C07H 2104, C07K 100, A61K 3900
Patent
active
061334332
ABSTRACT:
A DNA probe has been isolated which is capable of hybridizing to an oligonucleotide sequence coding for a polypeptide from a major 64 Kilodalton protein of human cytomegalovirus (HCMVgp64). The probe has a sequence of at least seventeen (17) to as many as seven hundred twenty-one (721) nucleotides. The DNA fragments coding for the major late protein of human cytomegalovirus (HCMVgp64) may be hybridized to DNA fragments of HCMV DNA from an individual having human cytomegalovirus infection. The major late protein of human cytomegalovirus (HCMVgp64) also reacts with T-lymphocytes of an individual after natural infection of that individual with human cytomegalovirus. Thus, the HCMVgp64 protein may be used as a vaccine to prevent HCMV infection.
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Clark Brian R.
Pande Hema
Riggs Arthur D.
Zaia John A.
City of Hope
Davenport Avis M.
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