Method for detection and determination of human serum albumin

Details Method for detection and determination of human serum albumin Method for detection and determination of human serum albumin

1990-07-20

1993-01-26

Housel, James C.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Glycoproteins

436164, 436172, G01N 3352

Patent

active

051822148

ABSTRACT:
An optical method for quantitative determination of human serum albumin (HSA) in biological liquids such as urine is based on the observation that the absorption and fluorescence of certain anionic cyanine dyes possessing a terminal cyano group and having the general formula ##STR1## are strongly affected by HSA. This approach is distinctly more sensitive than existing techniques, allowing the detection and quantization of micro-albuminuria (i.e. detection of HSA in the 1-10 mg per liter concentration range) at costs which are distinctly lower than those for existing immunological assays. It is also much more specific for HSA than existing assays based on dye binding. Because the dyes has long wave absorptions and emissions, use can be made of electro-optical components based on semiconductor technology.

REFERENCES:
patent: 4568647 (1986-02-01), Sanford

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