Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2007-11-06
2007-11-06
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S069600
Reexamination Certificate
active
10519824
ABSTRACT:
The invention relates to a diagnostic method for determining the von Willebrand factor (VWF) cleaving activity of ADAMTS-13 in a test medium during which the test medium is mixed with 0.5 to 5 U/ml of a von Willebrand factor (VWF) that does not contain ADAMTS-13, and after incubation, the ADAMTS-13 activity is determined based on the drop in the VWF-mediated aggregation of thrombocytes.
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Zheng, X. et al.: “Structure of von Willebrand Factor-cleaving Protease(ADAMTS13),a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura”; Journal of Biological Chemistry (2001) vol. 276, No. 44, pp. 41059-41063.
Poster shown at the 43rd Annual Metting of the American Society of Hematology on Dec. 8, 2001 in Orlando,Florida.
Abstract of the Poster shown at the 43rd Annual Meeting of the American Society of Hematology on Dec. 8, 2001 in Orlando,Florida.
Von Willebrand Factor 2002 Minutes, p. 4 (speech given at the SSC meeting on Jul. 20, 2002 in Boston, USA).
Abstract of a speech given on Nov. 11, 2001 in Hamburg, Germany.
Dade Behring Marburg GmbH
Gitomer Ralph
ProPat L.L.C.
Shen Bin
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