Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Fusion of cells
Reexamination Certificate
2000-09-01
2008-10-28
Campell, Bruce R. (Department: 1648)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Fusion of cells
C435S070200, C435S325000, C435S339100, C435S173400, C435S069600, C435S070100
Reexamination Certificate
active
07442550
ABSTRACT:
A method for detecting the expression of a polypeptide in cells and for detecting the interaction between a polypeptide and cells, ex vivo or in vitro, wherein the polypeptide is selected from the group consisting of: a peptide comprising the cyt domain of the envelope protein of the human endogenous retrovirus, HERV-W; a peptide comprising amino acids 448-538 of SEQ ID NO: 1; and a peptide comprising a sequence having, for any series of 20 amino acids, at least 80% identity with amino acids 448-538 of SEQ ID NO: 1. Detection is established by the fusogenic power of the polypeptide, which is demonstrated by syncytia formation.
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Blond Jean-Luc
Bouton Olivier
Cosset Francois-Loic
Lavillette Dimitri
Mallet Francois
Biomerieux
Campell Bruce R.
Institut National de la Sante et de la Recherche Medicale
Li Bao Qun
Oliff & Berridg,e PLC
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