Method for detecting target sequences by oscillation frequency

Details Method for detecting target sequences by oscillation frequency Method for detecting target sequences by oscillation frequency

1993-09-07

1996-09-03

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436 94, 436501, 422 681, 422 8201, C12Q 168, G01N 3348

Patent

active

055522742

ABSTRACT:
Methods for detecting target DNA's in a sample on the basis of oscillation frequency using nucleic acid sequences immobilized to the surface of an electrode of an elastic wave element, and DNA sensors for conducting the methods are described. These methods provide for highly sensitive detection of target DNA's in a sample.

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J. C. Andle et al., "An Acoustic Plate Mode Biosensor", Sensors and Actuators, vol. B8, No. 2, pp. 191-198, May 1992.
Y. Okahata et al., "Hybridization of Nucleic Acids Immobilized on a Quartz Crystal Microbalance", J. Am. Chem. Soc. vol. 114, pp. 8299-8300, 1992.
Richard C. Ebersole et al., "Amplified Mass Immunosorbent Assay with a Quartz Crystal Microbalance", J. A. Chem. Soc. vol. 110, pp. 8623-8628 (1988).
The Sangyou "Detection of Virus by the Use of Quartz Oscillator" (Laid Open Date: Aug. 4, 1992).

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