Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2005-10-03
2009-02-10
Ewoldt, G. R. (Department: 1644)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
Reexamination Certificate
active
07488474
ABSTRACT:
An object of the present invention is to provide a technique to distinguish between Tregcells and activated T cells in a live state. Another object of the present invention is to provide a pharmaceutical composition for immunostimulation that can reduce the number of Tregcells in vivo and effectively express the immune response of activated T cells. In the method of the present invention, Tregcells are detected from test cells containing (i) regulatory T cells and (ii) at least one type of cell selected from the group consisting of naive T cells and activated T cells, wherein expressions of folate receptor 4 on the surfaces of cells are measured and Tregcells are detected using the expressions as an indicator. The present invention uses anti-folate receptor 4 antibody or folate receptor 4-binding fragment as an active ingredient contained in a pharmaceutical composition for immunostimulation.
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Hirota Keiji
Sakaguchi Shimon
Yamaguchi Tomoyuki
Ewoldt G. R.
Juedes Amy E
Kyoto University
Riken
Sughrue & Mion, PLLC
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