Method for detecting procoagulant genetic and metabolic...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Reexamination Certificate

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10915018

ABSTRACT:
Methods for diagnosing and identifying genetic and metabolic factors associated with a physiologic procoagulant predisposition for and concurrent activation of the coagulation response in patients suffering from conditions such as chronic fatigue syndrome, fibromyalgia, Gulf War illness and cardiovascular disease are disclosed. Diagnostic assays utilized in the methods include measurement of blood levels of Protein C, Protein S, antithrombin, activated protein C resistance, prothrombin, plasminogen activator inhibitor-1, lipoprotein (a) and homocysteine. Treatment regimens include anticoagulant therapies comprising administering warfarin or heparin as needed.

REFERENCES:
patent: 5780255 (1998-07-01), Preda
patent: 2006/0068454 (2006-03-01), Okuda et al.
Sorensen et al (Thrombosis Research vol. 65, pp. 479-486, 1992).
Pedersen et al (Heart vol. 77, pp. 122-127, 1997).

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