Method for detecting perilymphatic fistula

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S004000

Reexamination Certificate

active

07863005

ABSTRACT:
It is an object of the present invention to provide a simple, reliable and low-invasive method to detect perilymph fistulas. The present invention provides a method for detecting a perilymph fistula, which comprises detecting the existence of Cochlin in body fluid existing in the middle ear.

REFERENCES:
patent: 4830024 (1989-05-01), Nashner et al.
patent: 6274554 (2001-08-01), Magal et al.
patent: 6730475 (2004-05-01), Robertson et al.
patent: 6913919 (2005-07-01), Botstein et al.
patent: 2002/0004228 (2002-01-01), Holloway
patent: 2003/0082646 (2003-05-01), Carey et al.
patent: 00/71081 (2000-11-01), None
Dictionary of Medicine, definition for the term “perilymph” (2000); Peter Collin Publishing, London: Peter Collin Publishing. Retrieved Oct. 21, 2008, from http://www.credoreference.com/entry/1051726/.
Wall et al. “Perilymph fistula pathophysiology” Otolaryngol Head Neck Surg. Jan. 1995;112(1):145-53.
Wolfe, S.L., Molecular and Cellular Biology, 1993, pp. 790-793.
The Academic Press Dictionary of Science and Technology, definition for the term “polyclonal” (1996) Oxford: Elsevier Science & Technology. Retrieved Oct. 22, 2008, from http://www.credoreference.com/entry/3144515/.
Ilkezono et al. “Cochlin-Tomoprotein: A Novel Perilymph-Specific Protein and a Potential Marker for the Diagnosis of Perilymphatic Fistula” Audiol Neurotol 2009;14:338-344.
Ikezono et al. “Identification of a novel Cochlin isoform in the perilymph: insights to Cochlin function and the pathogenesis of DFNA9” Biochemical and Biophysical Research Communications 314 (2004) 440-446.
Y. Asano et al., Prospects of Otolaryngology, 1991, vol. 34, No. 4, pp. 411-425, along with an English Language Summary.
K. Yoshioka, Prospects of Otolaryngology, 1983, vol. 26, Suppl. 6, pp. 517-539, along with an English Language Summary.
D.C. Fitzgerald, Ann. Otol. Rhinol. Laryngol., 2001, vol. 110, pp. 430-436.
I. Thalmann et al., Otolaryngology—Head and Neck Surgery, 1994, vol. 111, No. 3, pp. 273-280.
H. Kanzaki et al., “Koserodosho tokutei sikkan taisaku kenkyu jigyokyusei kodo kanon nancho ni kansuru cyosa kenkyu han/heisei 11 nendo hokokusho (Annual report 1999, by the Research project team regarding acute profound sensorineural hearingloss, Research project for specified diseases, the Ministry of Health, Labour and Welfare)”, 2000, pp. 41-41.
G. Bachmann et al., The Journal of Laryngology & Otology, 2001, vol. 115, pp. 132-135.
S.D. Rauch, The Laryngoscope, 2000, vol. 110, No. 4, pp. 545-552.
N.G. Robertson et al., Nature Genetics, 1998, vol. 20, pp. 299-303.
NCBI OMIM, http://www.ncbi.nlm.nih.gov., Cochlin Coch5B2, 2005, 5 pages.
M. Trexler et al., Eur. J. Biochem., 2000, vol. 267, pp. 5751-5757.
T. Ikezono et al., Biochimica et Biophysica Acta, 2001, vol. 1535, pp. 258-265.
N.G. Robertson, Hum. Mol. Genet., 2001, vol. 10, No. 22, pp. 2493-2500.
G. Kohler et al., Nature, 1975, vol. 256, pp. 495-497.
S. Shindo et al., “Cochlin Kanren Tanpaku o mochiita Kai-Lymph-ro Shindan no Kokoromi”, Dai 104 kai The Oto-Rhino-Laryngological Society of Japan, Inc., Sokai Gakujutsu Koenkai Yokoshu, vol. 106, No. 4, p. 106, Abstract #132 (2003).
N. Robertson et al., “Subcellular Localisation, Secretion, and Post-Translational Processing of Normal Cochlin, and of Mutants Causing the Sensorineural Deafness and Vestibular Disorder, DFNA9”, J. Med. Genet., vol. 40 pp. 479-486 (2003).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for detecting perilymphatic fistula does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for detecting perilymphatic fistula, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for detecting perilymphatic fistula will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2683224

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.