Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-11-10
2009-02-17
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07491504
ABSTRACT:
A method of detecting ovarian cancer in a female test subject comprising determining the amount of plasmenyl-PA or a biomarker having a mass charge ratio of approximately 655.3 in a sample of a bodily fluid taken from the female test subject and comparing the amount of plasmenyl-PA (or the biomarker) in the sample of the bodily fluid taken from the female test subject to a range of amounts of plasmenyl-PA (or the biomarker) found in samples of bodily fluids taken from a group of normal female subjects of the same species as the female test subject and lacking ovarian cancer, whereby a lower amount of the plasmenyl-PA (or the biomarker) in the sample of the bodily fluid taken from the female test subject indicates the presence of ovarian cancer.
REFERENCES:
patent: 5776753 (1998-07-01), Hillman et al.
patent: 6500633 (2002-12-01), Compton et al.
patent: 6830932 (2004-12-01), Danne et al.
patent: 2002/0123084 (2002-09-01), Mills et al.
patent: 2002/0150955 (2002-10-01), Mills et al.
patent: 2004/0137541 (2004-07-01), Mills et al.
patent: 2004/0143461 (2004-07-01), Watkins
Merchant, T.E., Kasimos, J.N., De Graaf, P.W., Minsky, B.D., Gierke, L.W., and Glonek, T. Phospholipid profiles of human colon cancer using 31P magnetic resonance spectroscopy. International Journal of Colorectal Disease, 1991. vol. 6, pp. 121-126.
Borsche, T. Plasmalogen levels in serum from patients with imaired carbohydrate or lipid metabolism and in elderly subjects with normal metabolic values. Archives of Gerontology and Geriatrics, 2001. vol. 32, pp. 283-294.
U.S. Appl. No. 11/601,076, filed Nov. 17, 2006, Confirmation No. 6866.
Stevens et al., “Class F Thy-1-negative Murine Lymphoma Cells Are Deficient in Ether Lipid Biosynthesis,”J. Biol. Chem., Sep. 1990, vol. 265, No. 26, pp. 15653-15658.
Zoeller et al., “Isolation of Animal Cell Mutants Deficient in Plasmalogen Biosynthesis and Peroxisome Assembly,”Proc. Natl. Acad. of Sci. of U.S.A., Jul. 1986, vol. 83, pp. 5170-5174.
Hale et al., “The selective activation of the cardiac sarcolemmal sodium-calcium exchanger by plasmalogenic phosphatidic acid produced by phospholipase D,”FEBS Letters, Jan. 1998, 422 (2), pp. 247-251.
Petricoin et al., Use of proteomic patterns in serum to identify ovarian cancer,The Lancet, Feb. 2002, 359 (9306), pp. 572-577.
Zhu et al., “Detection of cancer-specific markers amid massive mass spectral data,”PNAS USA, Dec. 2003, 100 (25), pp. 14666-14670.
Zhen Zhang et al., “Three Biomarkers Identified from Serum Proteomic Analysis for the Detection of Early Stage Ovarian Cancer,”Cancer Research, 64, 5882-5890, Aug. 15, 2004.
Han et al., “Diabetes-induced changes in specific lipid species in rat myocardium,”The Biochemical Journal, (2000), vol. 352 (Ptl) : 79-89.
Dueck et al., “The modulation of choline phosphoglyceride metabolism in human colon cancer,”Molecular and Cellular Biochemistry, (1996), vol. 162 (2) : 97-103.
Morita et al., “Phospholipid turnover in the inflamed intestinal mucosa: Arachidonic acid-rich phosphatidyl/plasmenyl-ethanolamine in the mucosa in inflammatory bowel disease,”Journal of Gastroenterology, (1999), vol. 34 (1) : 46-53.
Zhu et al., “Molecular species composition of glycerophospholipids in rat sciatic nerve and its alteration in streptozotocin-induced diabetes,”Biochimica et Biophysica Acta., (1993), vol. 1168 (1) : 1-12.
Yavin et al., “Docosahexaenoic Acid Abundance in the Brain: A Biodevice to Combat Oxidative Stress,”Nutr. Neuroscience, (2002), vol. 5 (3), 149-157.
Rapport and Alonzo, “Identification of Phosphatidal Choline as the Major Constituent of Beef Heart Lecithin,”J. Biol. Chem., (1955), 217 : 199-204.
Morikawa et al., “A Simple and Sensitive Determination for Plasmalogen Lysophosphatidylethanolamine in Rabbit Platelets,”Thrombosis Research, (1989), 55: 427-438.
Shaikh, “Assessment of Various Techniques for the Quantitative Extraction of Lysophospholipids from Myocardial Tissues,”Analytical Biochemistry, (1994), 216:313-321.
Engelmann et al., “Plasmalogen phospholipids as potential protectors against lipid peroxidation of low density lipoproteins,”Biochem. Biophys. Res. Commun., (1994), vol. 204, No. 3, 1235-1242.
Lee, “Biosynthesis and possible biological functions of plasmalogens”,Biochim. Biophys. Acta, (1998), 1394:129-145.
Sindelar et al., “The protective role of plasmalogens in iron-induced lipid peroxidation”,Free Radical Biol. Med., (1999), 26:318-324.
Confurius and Zwaal, “The Enzymatic Synthesis of Phosphatidylserine and Purification by CM-Cellulose Column Chromatography,”Biochim. Biophys. Acta, (1977), 488: 36-42.
Merchant et al., “Esophageal cancer phospholipids correlated with histopathologic findings: a31P NMR study”,NMR Biomed., (1999), 12(4):184-188.
Merchant et al., “31P magnetic resonance phospholipid profiles of neoplastic human breast tissues”,Br J Cancer, 1991), 63(5):693-698.
Leung and Sun, “Acyl Group Composition of Membrane Phospholipids in Mammary Tissues and Carcinoma Induced by Dimethylbenz (a) Anthracene,”Proc. Soc. Exp. Biol. Med., 152 (4) :671-676.
Albert and Anderson, Ether-linked glycerolipids in human brain trumors,Lipids, (1977), 12 (2) :188-192.
Tamiya-Koizumi et al., “Lipid composition of the plasma membrane isolated from hyperplastic nodules of rat liver”,J. Biochem., (1985), 97 (3) :773-779.
Koizumi et al., Comparative study of the phospholipid composition of plasma membranes isolated from rat primary hepatomas induced by 3′-methyl-4-dimethylaminoazobenzene and from normal growing rat livers,Cancer Res., (1980), 40 (3) :909-913.
Koizumi et al., “Rapid isolation and lipid characterization of plasma membranes from normal and malignant lymphoid cells of mouse,”Biochim. Biophys Acta., (1981), 649 (2) :393-403.
Kuliszkiewicz-Janus et al., “Application of31P MRS to the analysis of phospholipid changes in plasma of patients with acute leukemia”,Biochim. Biophys Acta., (2005), 1737 (1) : 11-15.
Farooqui and Horrocks, “Plasmalogens: workhorse lipids of membranes in normal and injured neurons and glia”,Neuroscientist, (2001) , 7 (3) :232-45.
English-language International Preliminary Report on Patentability and Written Opinion of the International Searching Authority, dated Jun. 5, 2008 for International Application PCT/US2006/043893 filed Nov. 22, 2006; Applicants: Frantz Biomarkers, LLC et al.
Hazen Stanley L.
Shan Lian
Frantz Biomarkers, LLC
Frishauf Holtz Goodman & Chick P.C.
Halvorson Mark
The Cleveland Clinic Foundation
Yu Misook
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