Method for detecting nucleic acid polymer

Details Method for detecting nucleic acid polymer Method for detecting nucleic acid polymer

1996-02-01

1999-02-16

Marschel, Ardin H.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436501, 436518, 436536, 536 221, 536 243, C12Q 168, G01N 33566, G01N 33567, G01N 33536

Patent

active

058719156

ABSTRACT:
The present invention has an object to provide an easy method for detecting a nucleic acid polymer in aqueous phase.
The present invention provides a method for detecting the amount of nucleic acid polymer, which comprises the steps of modifying an intercalator to be amphiphilic by using a hydrophobic group, spreading the amphiphilic intercalator on an aqueous solution containing a nucleic acid polymer to form a monolayer of said nucleic acid polymer and said amphiphilic intercalator at the gas-water interface, and measuring surface pressures per unit area of said monolayer.

REFERENCES:
patent: 5194393 (1993-03-01), Hugl et al.
Kajiyama et al. "Effect of Polycation in Subphase on Aggregation Structure of Monolayer and Langmuir-Blodgett Film of Anionic Amphiphile" Langmuir, vol. 9, pp. 760-765, 1993.
Uhlmann et al. "Antisense Oligonucleotides: A New Therapeutic Principle" Chemical Review, vol. 90, p.543, Jun. 1990.
Masaru Tanaka et al., "Preparation of Nucleic DNA Monolayer Complex by Polyionic Complex Process", Hokkaido University regional winter meeting of the Japanese Chemical Society held Feb. 2, 1995.(with English Abstract).

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