Chemistry: analytical and immunological testing – Nitrogen containing – Oxides of nitrogen
Patent
1992-04-22
1995-10-17
Housel, James C.
Chemistry: analytical and immunological testing
Nitrogen containing
Oxides of nitrogen
436 86, 436106, 436107, 436114, 436172, G01N 3300, G01N 2176
Patent
active
054590760
ABSTRACT:
Nitric oxide, nitrosonium, S-nitrosothiols, and S-nitroso-proteins can be detected in biological samples, using a method which involves injection of samples into a photolysis cell, prior to detection of chemiluminescence generated by the reaction between nitric oxide and ozone. To detect S-nitrosothiols and S-nitroso-proteins separate aliquots of the same samples are subjected to pretreatment with mercurous ion, and a protein-precipitating agent, respectively, and the resulting nitric oxide signals are compared to those generated by untreated samples. This method is useful for monitoring the levels of nitric oxide bioactivity in both normal physiological states, and disease states, such as septic shock, atherosclerosis, thrombosis, hyperhomocysteinemia, pulmonary hypertension, malignancy, infections and central nervous systems disorders.
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Loscalzo Joseph
Stamler Jonathan
Brigham and Women's Hospital
Herron Charles J.
Housel James C.
Olstein Elliot M.
Wallenhorst Maureen M.
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