Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-05-11
2010-12-14
Swartz, Robert P. (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C424S130100, C424S137100, C424S163100, C424S164100, C424S168100, C424S184100, C424S234100, C424S248100, C435S004000, C435S007100, C435S007320
Reexamination Certificate
active
07851166
ABSTRACT:
A method of detecting a surrogate marker for active tuberculosis involves obtaining first, second and third samples from a subject suspected of having active tuberculosis, diluting the first sample and exposing part of it to an immobilized mycolic acid antigen in a test vessel and part of it to an immobilized mycolic antigen in a control vessel. The second sample is exposed to mycolic acid antigen-containing liposomes and the third sample is exposed to liposomes not containing mycolic acid antigens. The second sample is added to the test vessel and the third to the control vessel and binding of antibodies to the mycolic acid and antigen in both the test and control vessel is detected. The degree of binding between the test and control vessels is compared and lesser binding in the test vessel is an indicator of the presence of antibodies to the mycolic acid antigen.
REFERENCES:
patent: 5721109 (1998-02-01), Yano et al.
patent: 6124105 (2000-09-01), Verschoor et al.
Schleicher et al., “Prevalence of anti-mycolic acid antibodies in patients with pulmonary tuberculosis co-infected with HIV,”Clinical chemistry and laboratory medicine, vol, 40, No. 9, Sep. 2002, pp. 882-887.
Pan et al., Anti-cord factor (trehalose 6,6′-dimycolate) IgG antibody in tuberculosis patients recognizes mycolic acid subclasses,Microbiology and immunology, vol. 43, No. 9, 1999, pp. 863-869.
Siko Dismore Gilbert Ramathudi
Van Wyngaardt Sandra
Verschoor Jan Adrianus
Robins & Pasternak LLP
Swartz Robert P.
The University of Pretoria
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