Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2004-11-08
2009-11-03
Lu, Frank W (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C435S287200, C536S023100, C536S024300, C536S024330
Reexamination Certificate
active
07611841
ABSTRACT:
A method for detecting the methylation of promoters using HpaII, a methylation-sensitive restriction enzyme. In such method, DNAs, derived from clinical samples or subjects to be diagnosed, are cut with HpaII, the cut DNAs are amplified by PCR with primers capable of amplifying CpG islands, and the presence or absence of the PCR amplification products is determined using a DNA chip for methylation detection. Unlike prior approaches, the inventive method allows the methylation of gene promoters to be detected in a simple and economical manner, and thus is useful for the diagnosis of diseases such as cancer that are characterized by methylation of gene promoters.
REFERENCES:
patent: 2003/0148326 (2003-08-01), Olek et al.
patent: 2005/0196792 (2005-09-01), Fodor et al.
patent: 2005/0202490 (2005-09-01), Makarov et al.
patent: 10-2004-0015705 (2004-03-01), None
patent: WO 01/26536 (2001-04-01), None
Adorjan, P. et al.,Nucleic Acid Res., 30:e21, 2002.
Ahlquist, D.A. et al.,Gastroenterol., 119:1219, 2000.
Chen, X.Q. et al.,Clin. Cancer Res., 5:2297, 1999.
Conner, B.J. et al.,PNAS, 80:278, 1983.
Cross, S.H. et al.,Nat. Genet., 6:236, 1994.
Cross, S.H. & Bird A.P.,Curr. Opin. Gene Develop., 5:309, 1995.
De Smet, C. et al.,Mol. Cell. Bio., 19;7327, 1999.
Eads, C.A. et al.,Nucleic Acid Res., 28:e32, 2000.
Esteller, M. et al.,Cancer Res., 59:67, 1999.
Goessl, C. et al.,Cancer Res., 60:5941, 2000.
Hatada, I. et al.,PNAS, 88:9523,1991.
Herman, J.G. et al.,PNAS, 93:9821, 1996.
Huang, T.H. et al.,Hum. Mol. Genet., 8:459, 1999.
Kopreski, M.S. et al.,Clin. Cancer Res., 5:1961, 1999.
Landegren, U., Bioessays, 15:761, 1993.
Landegren, U. et al.,Science, 241:1077, 1988.
Liang, G. et al.,Methods, 27:150, 2002.
Malik, K. & Brown, K.W.;Brit. J. Cancer, 83:1583, 2000.
Miyashiro, I. et al.,Clin. Chem., 47:505, 2001.
Palmisano, W.A. et al.,Cancer Res., 60:5954, 2000.
Robertson, K.D. & Jones, P.A.,Carcinogensis, 21:461, 2000.
Saiki, R.K. et al.,Nature, 324:163, 1986.
Sanchez-Cespedes, M. et al.,Cancer Res., 60:892, 2000.
Sato, N. et al.,Cancer Research, 63:3735, 2003.
Shi, H. et al.,J. Cell Biochem., 88:138, 2003.
Singal, R. & Ginder, G.D.,Blood, 93:4059, 1999.
Sozzi, G. et al.,Clin. Cancer Res., 5:2689, 1999.
Sueoka, E. et al.,Cancer Res., 59:1404, 1999.
Tsou, J.A. et al.,Oncogene, 21:5450, 2002.
Virmani, A.K. et al.,J. Natl. Cancer Institut., 92:1303, 2000.
Xiong, Z. & Laird, P.W.,Nucleic Acid Res., 25:2532, 1997.
Yan, P.S. et al.,Clin. Cancer Res., 6:1432, 2000.
An Sungwhan
Kim Myung-Soon
Lee Sun-Woo
Oh Tae-Jeong
Woo Suk-Kyung
Genomictree, Inc.
Hultquist Steven J.
Intellectual Property / Technology Law
Lu Frank W
Reynolds Kelly K.
LandOfFree
Method for detecting methylation of promoter using... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for detecting methylation of promoter using..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for detecting methylation of promoter using... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4077729