Method for detecting melanin-containing matter

Details Method for detecting melanin-containing matter Method for detecting melanin-containing matter

1986-06-02

1988-06-07

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 530387, 530389, 540594, 540595, A61K 4900, A61K 4300, A61K 3900

Patent

active

047495596

ABSTRACT:
The present invention discloses a method of detecting melanin containing matter comprising reacting melanin containing matter with an enantiomer of 2, 3, 4, 5-tetrahydro-3-methyl-5 phenyl-1H-3-benzazepin-7-ol and determining the binding of said enantiomer with melanin. The invention also describes a method of delivering cytotoxic level of gamma radiation to pigmented melanoma comprising administering to a body carrying pigmented melanoma a cytotoxically effective radiation dosage of .sup.125 I-enantiomer of 2, 3, 4, 5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol having specific binding affinity for said melanoma. Other applications of the invention have also been described.

REFERENCES:
patent: 3393192 (1968-07-01), Walter et al.
patent: 4210749 (1980-07-01), Shetty
patent: 4382029 (1983-05-01), Holden et al.
patent: 4460559 (1984-07-01), Goldenberg
patent: 4549988 (1985-10-01), Fryer et al.
patent: 4661347 (1987-04-01), Muller-Eberhard et al.
O'Boyle et al, "Structural Determinants of Selective Affinity for Brain D-1 Dopamine Receptors within a Series of 1-phenyl-1H-3-benzazipine Analogs of SK&F 38393 and SCH 23390", Chemical Abstracts, vol. 104, (2/86) #28373p.

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