Chemistry: analytical and immunological testing – Heterocyclic carbon compound – Diverse hetero atoms in same or different rings
Patent
1988-10-28
1991-05-14
Lacey, David L.
Chemistry: analytical and immunological testing
Heterocyclic carbon compound
Diverse hetero atoms in same or different rings
436816, 436901, 436 93, G01N 3300
Patent
active
050155890
ABSTRACT:
A method for detecting the presence of drug metabolites in the meconium of newborn infants is described. The method involves separation of the drug metabolites from meconium in solution and then assaying the solution for the presence of the drug metabolites. The method is particularly useful for detection of cocaine, morphine and cannabinoids; however, any drug metabolite in the infant meconium can be tested. Conventional assay methods are used for the drug metabolites in the solutions derived from the meconium. The method provides for early detection of drug presence in infants which contribute to infant illness.
REFERENCES:
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Ostrea, E. M. et al.,. Pediatr. Res. 17:153A (1983).
Ostrea, Jr., E. M. et al., "The Detection of Heroin, Cocaine and Cannabinoid Metabolites in the Stools of Infants of Drug Dependent Mothers: Clinical Significance", Pediatric Research, 1987: 21:240A.
Zelson, C. et al., Pediatrics, 48:178 (1971).
Ostrea et al., J. Pediratr, 88: 642-645 (1976).
Halstead et al., Clin. Biochem, 21: 59-61 (1988).
Ostrea et al., Dev Pharmacol. Ther., 1: 163-170 (1980).
Board of Governors of Wayne State University
Lacey David L.
McLeod Ian C.
Redding David
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