Chemistry: analytical and immunological testing – Heterocyclic carbon compound – Diverse hetero atoms in same or different rings
Patent
1991-04-26
1993-02-09
Housel, James C.
Chemistry: analytical and immunological testing
Heterocyclic carbon compound
Diverse hetero atoms in same or different rings
436161, 436172, 436173, 436804, 436816, 436901, 435 71, 435 772, 435 79, G01N 3300
Patent
active
051852675
ABSTRACT:
An improved method for detecting the presence of durg metabolites in the meconium of newborn infants is described. The method involves a single step extraction of the drug metabolites from meconium using a buffered aqueous solution containing methanol in an amount between about 10 and 30% by volume and buffered to a pH between 6 and 7 and then assaying the extract individually for the presence of the drug metabolites. The method is particularly useful for detection of cocaine, morphine, cannabinoid and amphetamine metabolites; however, any drug metabolite in the infant meconium can be tested if it is extracted by the solution from the meconium. Various assay methods are used for the drug metabolites in the solutions derived from the meconium, including immunoassays, fluorescent assays and mass spectroscopy. The method provides for early detection of drug presence in newborn infants which contribute to infant illness.
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Housel James C.
McLeod Ian C.
Redding David
The Board of Governors of Wayne State University
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